Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

The prevalence of type‐2 diabetes (T2D) is increasing significantly throughout the globe
since the last decade. This heterogeneous and multifactorial disease, also known as insulin …

Membrane and protein traffic in the secretory and endocytic pathways is mediated by
vesicular transport. Recent studies of certain key regulators of vesicular transport, the Rab …

Rab27, a member of the small GTPase Rab family, is widely conserved in metazoan, and
two Rab27 isoforms, Rab27A and Rab27B, are present in vertebrates. Rab27A was the first …

Insulin release from pancreatic β-cells plays an essential role in blood glucose homeostasis.
Several proteins controlling insulin exocytosis have been identified, but the factors …

NeuroD, a transactivator of the insulin gene, is critical for development of the endocrine
pancreas, and NeuroD mutations cause MODY6 in humans. To investigate the role of …

Recent findings demonstrated the importance of microRNAs (miRNAs) in the vasculature
and the orchestration of lipid metabolism and glucose homeostasis. MiRNA networks …

Fine-tuning of insulin secretion from pancreatic β-cells participates in blood glucose
homeostasis. Defects in this process can lead to chronic hyperglycemia and diabetes …

Bone marrow derived stem cells (BMSCs) transplantation are viewed as a promising
therapeutic candidate for spinal cord injury (SCI). However, the inflammatory …

Rab27A was the only Rab protein whose dysfunction was found to cause human
immunodeficiency. Since Griscelli syndrome patients (ie, Rab27A-deficient) exhibit silvery …