Spontaneous subarachnoid haemorrhage

J Claassen, S Park - The Lancet, 2022 - thelancet.com
Subarachnoid haemorrhage (SAH) is the third most common subtype of stroke. Incidence
has decreased over past decades, possibly in part related to lifestyle changes such as …

Pathophysiology of delayed cerebral ischemia after subarachnoid hemorrhage: a review

WS Dodd, D Laurent, AS Dumont… - Journal of the …, 2021 - Am Heart Assoc
Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …

Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study

JP Dreier, MKL Winkler, S Major, V Horst, S Lublinsky… - Brain, 2022 - academic.oup.com
Focal brain damage after aneurysmal subarachnoid haemorrhage predominantly results
from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The …

Migraine Aura, transient ischemic attacks, stroke, and dying of the brain share the same key pathophysiological process in neurons driven by Gibbs–Donnan forces …

CL Lemale, J Lückl, V Horst, C Reiffurth… - Frontiers in cellular …, 2022 - frontiersin.org
Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …

Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage

J Chen, M Li, Z Liu, Y Wang, K Xiong - Frontiers in Cellular …, 2022 - frontiersin.org
Subarachnoid haemorrhage (SAH) is a common cerebrovascular disease with high
disability and mortality rates worldwide. The pathophysiological mechanisms involved in an …

How to diagnose delayed cerebral ischaemia and symptomatic vasospasm and prevent cerebral infarction in patients with subarachnoid haemorrhage

V Rass, R Helbok - Current opinion in critical care, 2021 - journals.lww.com
How to diagnose delayed cerebral ischaemia and symptomatic v... : Current Opinion in Critical
Care How to diagnose delayed cerebral ischaemia and symptomatic vasospasm and prevent …

Aneurysmal subarachnoid hemorrhage

DY Chung, M Abdalkader… - Neurologic clinics, 2021 - neurologic.theclinics.com
Aneurysmal subarachnoid hemorrhage (SAH) is a neurologic emergency that requires
prompt diagnosis and management to prevent life-threatening rebleeding and optimize …

Antiplatelet therapy in aneurysmal subarachnoid hemorrhage: an updated meta-analysis

KS Lee, C Lee, PS Dhillon, R Kirollos, VDW Nga… - Neurosurgical …, 2023 - Springer
Antiplatelet therapy (AT) may serve to reduce the effects of aneurysmal subarachnoid
hemorrhage (aSAH)-induced pro-coagulant state in the cerebral circulation. Several studies …

Spreading depolarization and angiographic spasm are separate mediators of delayed infarcts

V Horst, V Kola, CL Lemale, S Major… - Brain …, 2023 - academic.oup.com
In DISCHARGE-1, a recent Phase III diagnostic trial in aneurysmal subarachnoid
haemorrhage patients, spreading depolarization variables were found to be an independent …

Similarities in the electrographic patterns of delayed cerebral infarction and brain death after aneurysmal and traumatic subarachnoid hemorrhage

JP Dreier, CL Lemale, V Horst, S Major, V Kola… - Translational Stroke …, 2024 - Springer
While subarachnoid hemorrhage is the second most common hemorrhagic stroke in
epidemiologic studies, the recent DISCHARGE-1 trial has shown that in reality, three …