Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Metabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during
proliferation, migration, stemness and differentiation. Src is a node of several signals …

The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

Breast cancer progression involves multiple genetic events, which can activate dominant-
acting oncogenes and disrupt the function of specific tumor suppressor genes. This article …

One arising challenge in the treatment of breast cancer is the development of therapeutic
resistance to trastuzumab, an antibody targeting the human epidermal growth factor receptor …

Abstract The Human Epidermal Growth Factor Receptor (HER) proteins family, which
includes HER2, are membrane-bound receptors that activate many intracellular pathways …

Hypofunction of the N-methyl d-aspartate subtype of glutamate receptor (NMDAR) is
hypothesized to be a mechanism underlying cognitive dysfunction in individuals with …

Despite the initial effectiveness of the tyrosine kinase inhibitor lapatinib against HER2 gene-
amplified breast cancers, most patients eventually relapse after treatment, implying that …

Chronic obstructive pulmonary disease (COPD) and lung cancer are frequently caused by
tobacco smoking. However, these diseases present opposite phenotypes involving redox …

Epidermal growth factor (EGF) binding to its receptor (EGFR) activates several signaling
intermediates, including Akt, leading to control of cell survival and metabolism …