Small-ring heterocycles have found many applications both as useful starting materials in
the synthesis of more elaborate structures and as valuable targets of synthesis. Our review …

Rapid advancements in genomics have brought a better understanding of molecular
mechanisms for various pathologies and identified a number of highly attractive target …

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …

More than a decade ago, the question was raised by Sweeney if aziridines are epoxides'
ugly cousins? 1 The overview on the biological properties, synthetic accessibility, and useful …

Conspectus Researchers continue to develop chemoselective synthesis strategies with the
goal of rapidly assembling complex molecules. As one appealing approach, chemists are …

Entry to bioactive boropeptides: MIDA‐containing α‐boryl isocyanides are isolable
molecules which allow one‐step access to boroalkyl‐functionalized heterocycles as well as …

Isocyanides were formally discovered by Gautier1 and Hofmann2 in 1867 but the history of
isocyanide chemistry in fact predates this discovery. Lieke carried out the first isocyanide …

We introduce a new and highly efficient synthetic protocol towards multifunctional
fluorescent cyclopeptides by solid‐phase peptide macrocyclization via dipyrrin construction …

In contrast to normal C-substituted isocyanates, nitrogen-substituted isocyanates (N-
isocyanates) are rare. Their high reactivity and amphoteric/ambident nature has prevented …

The cyclization of peptides is a valuable strategy for the development of binding motifs to
target proteins with improved affinity. Microtubules (MTs) are important targets for …