Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

A Galleu, Y Riffo-Vasquez, C Trento, C Lomas… - Science translational …, 2017 - science.org
The immunosuppressive activity of mesenchymal stromal cells (MSCs) is well documented.
However, the therapeutic benefit is completely unpredictable, thus raising concerns about …

Concise review: cancer cells, cancer stem cells, and mesenchymal stem cells: influence in cancer development

F Papaccio, F Paino, T Regad… - Stem cells …, 2017 - academic.oup.com
Tumors are composed of different types of cancer cells that contribute to tumor
heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an …

Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications

ME Castro-Manrreza… - Journal of immunology …, 2015 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiation into
mesenchymal lineages and that can be isolated from various tissues and easily cultivated in …

Mesenchymal stem cells migration homing and tracking

A Sohni, CM Verfaillie - Stem cells international, 2013 - Wiley Online Library
In this review, we discuss the migration and homing ability of mesenchymal stem cells
(MSCs) and MSC‐like cells and factors influencing this. We also discuss studies related to …

Immunological characterization of multipotent mesenchymal stromal cells—The International Society for Cellular Therapy (ISCT) working proposal

M Krampera, J Galipeau, Y Shi, K Tarte, L Sensebe - Cytotherapy, 2013 - Elsevier
Cultured mesenchymal stromal cells (MSCs) possess immune regulatory properties and are
already used for clinical purposes, although preclinical data (both in vitro and in vivo in …

Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine

PS Frenette, S Pinho, D Lucas… - Annual review of …, 2013 - annualreviews.org
Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into
bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs …

[HTML][HTML] Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and …

X Li, J Bai, X Ji, R Li, Y Xuan… - … journal of molecular …, 2014 - spandidos-publications.com
In the present study, we compared mesenchymal stem cells (MSCs) derived from 4 different
sources, human bone marrow (BM), adipose tissue (AT), umbilical cord Wharton's Jelly (WJ) …

[HTML][HTML] A phase 3 randomized study of remestemcel-L versus placebo added to second-line therapy in patients with steroid-refractory acute graft-versus-host disease

P Kebriaei, J Hayes, A Daly, J Uberti, DI Marks… - Biology of Blood and …, 2020 - Elsevier
Uncontrolled studies have suggested that bone marrow-derived mesenchymal stem cells
(MSCs) may be effective against acute graft-versus-host disease (aGVHD). We conducted a …