Aging, frailty and complex networks
When people age their mortality rate increases exponentially, following Gompertz's law.
Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses …
Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses …
Examination of the dimensions of biological age
SM Jazwinski, S Kim - Frontiers in genetics, 2019 - frontiersin.org
The concept of biological age has been used more and more frequently in aging research in
attempts to measure the progress of the biological aging process as opposed to the simple …
attempts to measure the progress of the biological aging process as opposed to the simple …
Sedentary behavior and physical activity are independent predictors of successful aging in middle‐aged and older adults
S Dogra, L Stathokostas - Journal of aging research, 2012 - Wiley Online Library
Background. Sedentary behavior is emerging as an important risk factor for poor health.
Physical activity has proven to be important in determining overall successful aging (SA) …
Physical activity has proven to be important in determining overall successful aging (SA) …
The last two decades of life course epidemiology, and its relevance for research on ageing
The term 'life course epidemiology'was coined in 1997 with the publication of the first edition
of A Life Course Approach to Chronic Disease Epidemiology. 1 This book reviewed the pre …
of A Life Course Approach to Chronic Disease Epidemiology. 1 This book reviewed the pre …
Homeostatic dysregulation proceeds in parallel in multiple physiological systems
An increasing number of aging researchers believes that multi‐system physiological
dysregulation may be a key biological mechanism of aging, but evidence of this has been …
dysregulation may be a key biological mechanism of aging, but evidence of this has been …
A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
AA Cohen, E Milot, J Yong, CL Seplaki, T Fülöp… - Mechanisms of ageing …, 2013 - Elsevier
Previous studies have identified many biomarkers that are associated with aging and related
outcomes, but the relevance of these markers for underlying processes and their …
outcomes, but the relevance of these markers for underlying processes and their …
Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging
Human aging is a lifelong process characterized by a continuous trade-off between pro-and
anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic …
anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic …
Complex systems dynamics in aging: new evidence, continuing questions
AA Cohen - Biogerontology, 2016 - Springer
There have long been suggestions that aging is tightly linked to the complex dynamics of the
physiological systems that maintain homeostasis, and in particular to dysregulation of …
physiological systems that maintain homeostasis, and in particular to dysregulation of …
Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review
Peripheral inflammation and gait speed alterations are common in several neurological
disorders and in the aging process, but the association between the two is not well …
disorders and in the aging process, but the association between the two is not well …
Air pollution stress and the aging phenotype: the telomere connection
DS Martens, TS Nawrot - Current environmental health reports, 2016 - Springer
Aging is a complex physiological phenomenon. The question why some subjects grow old
while remaining free from disease whereas others prematurely die remains largely …
while remaining free from disease whereas others prematurely die remains largely …