Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …

Breast cancer is considered one of the utmost neoplastic diseases globally, with a high
death rate of patients. Over the last decades, many approaches have been studied to early …

There is a growing interest in engineering hydrogels for 3D tissue and disease models. The
major motivation is to better mimic the physiological microenvironment of the disease and …

Osteoarthritis (OA) is a serious chronic and degenerative disease that increasingly occurs in
the aged population. Its current clinical treatments are limited to symptom relief and cannot …

Simple Summary Immunotherapies are emerging as promising strategies to cure cancer and
extend patients' survival. Efforts should be focused, however, on the development of …

Currently, breast carcinoma is the most common form of malignancy and the main cause of
cancer mortality in women worldwide. The metastasis of cancer cells from the primary tumor …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

Many of the existing three-dimensional (3D) cancer models in vitro fail to represent the entire
complex tumor microenvironment composed of cells and extra cellular matrix (ECM) and do …

Chemoradiotherapy, as a well-established paradigm to treat various cancers, still calls for
novel strategies. Recently, gold nanoparticles (AuNPs) have been shown to play an …