Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the …

Cancer arises from a stepwise accumulation of genetic changes that liberates neoplastic
cells from the homeostatic mechanisms that govern normal cell proliferation. In humans, at …

Abstract Tumor Treating Fields (TTFields) are low intensity, intermediate frequency,
alternating electric fields. TTFields are a unique anti-mitotic treatment modality delivered in a …

Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe
developmental defects, yet the molecular mechanisms explaining its effects on cellular …

Genomic DNA copy number alterations are key genetic events in the development and
progression of human cancers. Here we report a genome-wide microarray comparative …

An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells.
Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has …

In mitotic cells, an error in chromosome segregation occurs when a chromosome is left near
the spindle equator after anaphase onset (lagging chromosome). In PtK1 cells, we found …

A “spindle assembly” checkpoint has been described that arrests cells in G1 following
inappropriate exit from mitosis in the presence of microtubule inhibitors. We have here …

Tumor evolution presents a formidable obstacle that currently prevents the development of
truly curative treatments for cancer. In this perspective, we advocate for the hypothesis that …

Centrosomes play critical roles in processes that ensure proper segregation of
chromosomes and maintain the genetic stability of human cells. They contribute to mitotic …