Recent advances have driven the development of stem cell-derived, self-organizing, three-
dimensional miniature organs, termed organoids, which mimic different eye tissues …

The prevalence of chronic fundus diseases is increasing with the aging of the general
population. The treatment of these intraocular diseases relies on invasive drug delivery …

Background Human-induced pluripotent stem cell-derived retinal organoids are a valuable
tool for disease modelling and therapeutic development. Many efforts have been made over …

Mutations in eyes shut homolog (EYS), a gene predominantly expressed in the
photoreceptor cells of the retina, are among the most frequent causes of autosomal …

Purpose As an alternative and desirable approach for regenerative medicine, human
induced pluripotent stem cell (hiPSC) technology raises the possibility of developing patient …

Age-related macular degeneration and retinitis pigmentosa are degenerative retinal
diseases that cause severe vision loss. Early clinical trials involving transplantation of …

Inherited retinal degeneration is a term used to describe heritable disorders that result from
the death of light sensing photoreceptor cells. Although we and others believe that it will be …

Background X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1
gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1 …

In recent decades, many researchers have attempted to restore vision via transplantation of
retina/retinal cells in eyes with retinal degeneration. The advent of induced pluripotent stem …

Human retinal organoids have become indispensable tools for retinal disease modeling and
drug screening. Despite its versatile applications, the long timeframe for their differentiation …