Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain …

The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …

The progress over the last 30 years in defining the role of excitatory amino acids in normal
physiological function and in the abnormal neuronal activity of epilepsy has been reviewed …

Since it was discovered that the anti-hypertensive agent ifenprodil has neuroprotective
activity through its effects on NMDA (N-methyl-D-aspartate) receptors, a determined effort …

The interaction of Ro 25–6981 with N-methyl-d-aspartate (NMDA) receptors was
characterized by a variety of different tests in vitro. Ro 25–6981 inhibited 3H-MK-801 binding …