A review on the pharmacological effects of vitexin and isovitexin

M He, JW Min, WL Kong, XH He, JX Li, BW Peng - Fitoterapia, 2016 - Elsevier
Vitexin and isovitexin are active components of many traditional Chinese medicines, and
were found in various medicinal plants. Vitexin (apigenin-8-C-glucoside) has recently …

Natural products as modulators of sirtuins

B Karaman Mayack, W Sippl, F Ntie-Kang - Molecules, 2020 - mdpi.com
Natural products have been used for the treatment of human diseases since ancient history.
Over time, due to the lack of precise tools and techniques for the separation, purification, and …

Aspalathus linearis (Rooibos)–a functional food targeting cardiovascular disease

C Smith, A Swart - Food & function, 2018 - pubs.rsc.org
Increasing consumer bias toward natural products and the considerable wealth of
indigenous knowledge has precipitated an upturn in market-driven research into potentially …

Safety Assessment of Phytochemicals Derived from the Globalized South African Rooibos Tea (Aspalathus linearis) through Interaction with CYP, PXR, and P-gp

OI Fantoukh, OR Dale, A Parveen… - Journal of agricultural …, 2019 - ACS Publications
Rooibos tea (Aspalathus linearis) is a well-known South African herbal tea enjoyed
worldwide. Limited reports indicate the potential of rooibos tea to alter the activity of certain …

Metabolic profiling of four South African herbal teas using high resolution liquid chromatography-mass spectrometry and nuclear magnetic resonance

F Malongane, LJ McGaw, H Nyoni, FN Mudau - Food chemistry, 2018 - Elsevier
Increased preference to herbal drinks has led to global interest in the use and production of
different plant species for the preparation of various drink formulations. Medicinal properties …

[HTML][HTML] Extended steroid profiling in H295R cells provides deeper insight into chemical-induced disturbances of steroidogenesis: Exemplified by prochloraz and …

MC Jäger, M Patt, V González-Ruiz, J Boccard… - Molecular and cellular …, 2023 - Elsevier
Human adrenocortical H295R cells have been validated by the OECD Test Guideline 456 to
detect chemicals disrupting testosterone and 17β-estradiol (estradiol) biosynthesis. This …

Rooibos (Aspalathus linearis) facilitates an anti-inflammatory state, modulating IL-6 and IL-10 while not inhibiting the acute glucocorticoid response to a mild novel …

C Smith, AC Swart - Journal of Functional Foods, 2016 - Elsevier
Rooibos is rich in polyphenols with a high anti-oxidant capacity, modulating adrenal
steroidogenesis while also influencing cytokine levels. The aim of this study was to …

Aspalathin: a rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea)

SK Chaudhary, M Sandasi, F Makolo… - Phytochemistry …, 2021 - Springer
Abstract Aspalathin (2′, 3, 4, 4′, 6′-pentahydroxy-3′-C-β-D-
glucopyranosyldihydrochalcone) is a natural C-linked glucosyl dihydrochalcone present in …

The effects of tea polyphenols on emotional homeostasis: Understanding dementia risk through stress, mood, attention & sleep

D Minné, J Stromin, T Docrat, P Engel-Hills… - Clinical Nutrition …, 2023 - Elsevier
Decades of research provide evidence that certain phytochemicals in tea (Camellia
sinensis) and other herbal beverages are protective against the development of sporadic …

Translation of preclinical ethnomedicine data in LMICs: the example of rooibos

L Pretorius, C Smith - Frontiers in Pharmacology, 2023 - frontiersin.org
All disease, but especially non-communicable diseases, are related to dysfunction of one or
more regulatory systems. In developing countries, long-term management of patients with …