Diabetes mellitus (DM) is one of the greatest public health threats in modern societies.
Although during a few years it was suggested that DM had no significant effect in male …

Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …

Pre-diabetes, a risk factor for type 2 diabetes development, leads to metabolic changes at
testicular level. Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) and …

Elevated estradiol levels are correlated with male infertility. Causes of hyperestrogenism
include diseases of the adrenal cortex, testis or medications affecting the hypothalamus …

Androgen/androgen receptor (AR) signaling plays pivotal roles in the prostate development
and homeostasis as well as in the progression of prostate cancer (PCa). Androgen …

Oxidative stress is a well-established event in the pathology of several neurobiological
diseases. Sirt3 is a nicotinamide adenine nucleotide (NAD+)-dependent protein deacetylase …

Spermatogenesis is contingent upon hormones and growth factors acting through endocrine
and paracrine pathways either in vivo or in vitro. Sertoli cells (SCs) furnish essential factors …

Background and Purpose M etformin is commonly used to treat type 2 diabetes (T2D). While
new clinical applications have been ascribed to metformin, including treatment of …

The incidence of type 2 diabetes mellitus and its prodromal stage, pre-diabetes, is rapidly
increasing among young men, leading to disturbances in testosterone synthesis. However …

Melatonin co-operates with insulin in the regulation of glucose homeostasis. Within the
testis, glucose metabolism in the somatic Sertoli cells (SCs) is pivotal for spermatogenesis …