The complexity of glioblastoma multiforme (GBM) and its distinct pathophysiology belong to
a unique brain microenvironment and its cellular interactions. Despite extensive evidence of …

Glioblastoma multiforme (GBM), classified as World Health Organization grade IV
astrocytoma, is the deadliest adult cancer of the central nervous system. An important …

Postoperative acute kidney injury (AKI) is a severe complication after liver transplantation
(LT). Its deterioration and magnification lead to the increase in mortality. Connexin43 (Cx43) …

Suicide gene therapy of glioma based on herpes simplex virus type I thymidine kinase (HSV-
TK) and prodrug ganciclovir (GCV) suffers from the lack of efficacy in clinical trials, which is …

Intestinal injury has long been considered to play a crucial role in the pathophysiology of
sepsis and has even been characterized as the “motor” of it. Thus, we explored the effects of …

Gap junctions are specialized regions of the plasma membrane containing clusters of
channels that provide for the diffusion of ions and small molecules between adjacent cells. A …

MicroRNA (miRNA) holds promise as a novel therapeutic tool for cancer treatment.
However, the transfection efficiency of current delivery systems represents a bottleneck for …

The extreme aggressiveness of pancreatic ductal adenocarcinoma (PDA) has been
associated with blocked gap junctional intercellular communication (GJIC) and the presence …

HepaCAM (GlialCAM) is frequently deleted in carcinomas, and reintroduction of hepaCAM
into transformed cell lines reduces cellular growth and induces senescence. Mutations in …

Gemcitabine is a nucleoside analogue with anticancer activity. Inside the cell, it is
sequentially phosphorylated to generate the active drug. Phosphorylated nucleoside …