Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an
opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage …

Abstract Vaccines targeting Streptococcus pneumoniae (Spn) are limited by dependence on
capsular polysaccharide and its serotype diversity. More broadly-based approaches using …

Streptococcus pneumoniae (Spn) is a common cause of respiratory infection, but also
frequently colonizes the nasopharynx in the absence of disease. We used mass cytometry to …

Successful colonization of a host requires bacterial adaptation through genetic and
population changes that are incompletely defined. Using chromosomal barcoding and high …

ABSTRACT Group A Streptococcus (GAS) is the etiologic agent of numerous high-morbidity
and high-mortality diseases. Infections are typically highly proinflammatory. During the …

The dynamics underlying respiratory contagion (the transmission of infectious agents from
the airways) are poorly understood. We investigated host factors involved in the …

Capsule-switch mutants were compared to analyze how serotype affects the success of
Streptococcus pneumoniae (Spn) during colonization and transmission. Strains of multiple …

The opportunistic pathogen Streptococcus pneumoniae has dual lifestyles: one of an
asymptomatic colonizer in the human nasopharynx and the other of a deadly pathogen …

Experimental evolution is a powerful technique to understand how populations evolve from
selective pressures imparted by the surrounding environment. With the advancement of …

Infants are highly susceptible to invasive respiratory and gastrointestinal infections. To
elucidate the age-dependent mechanism (s) that drive bacterial spread from the mucosa, we …