Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to
improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation …

Background Lifestyle issues contribute to the development of obesity, type 2 diabetes, and
cardiovascular disease. Together with appropriate diet and exercise, nutraceuticals may …

After oral intake of drugs, drugs go through the first pass metabolism in the gut and the liver,
which greatly affects the final outcome of the drugs' efficacy and side effects. The first pass …

Abstract Labrasol® ALF (Labrasol®), is a non-ionic surfactant excipient primarily used as a
solubilising agent. It was investigated here as an intestinal permeation enhancer in isolated …

Sugar fatty acid esters are an interesting class of non-ionic, biocompatible and
biodegradable sugar-based surfactants, recently emerged as a valid alternative to the …

Oral delivery of macromolecules requires permeation enhancers (PEs) adaptable to
formulation. Sucrose laurate (SL)(D1216), a food grade surfactant, was assessed in Caco-2 …

Abstract Ile-Pro-Pro (IPP) and Leu-Lys-Pro (LKP) are food-derived antihypertensive peptides
which inhibit angiotensin-converting enzyme (ACE) and may have potential to attenuate …

This study aimed to examine the role of thiamine in the local inflammation of ruminal
epithelium caused by high-concentrate diets. Eighteen mid-lactating (148±3 d in milk; milk …

The stereoselective synthesis of biobased nonionic sugar surfactants (polyhydroxy
surfactants), which are thought to be safer, more affordable, plentiful, biodegradable …

To investigate the effect of sodium butyrate on high-concentrate diet-induced local
inflammation of the rumen epithelium, 18 midlactating dairy goats were randomly assigned …