In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …

The complement system was traditionally known as an effector arm of humoral immunity.
Today we also recognize it as a main element of the innate immune system. In blood and …

Complement is an innate immune system that is a first line of defense against pathogens
and facilitates elimination of apoptotic and injured cells. During complement activation, the …

Decay-accelerating factor (Daf) dissociates C3/C5 convertases that assemble on host cells
and thereby prevents complement activation on their surfaces. We demonstrate that during …

Orally applied nondigestible carbohydrates (NDC) have been associated with immune-
modulating effects and other health benefits. The effects of prebiotic carbohydrates have …

There is an ongoing need for new adjuvants to facilitate development of vaccines against
HIV, tuberculosis, malaria and cancer, amongst many others. Unfortunately, the most potent …

Currently, there is a significant rise in the development and clinical use of a unique class of
pharmaceuticals termed as Biopharmaceuticals or Biologics, in the management of a range …

The innate immune system provides sophisticated defense mechanisms to protect complex
macroorganisms from the attack of microorganisms. Among those, the complement system …

We report a novel isoform of β-d-[2→ 1] poly (fructo-furanosyl) α-d-glucose termed delta
inulin (DI), comparing it with previously described alpha (AI), beta (BI) and gamma (GI) …

There has been a recent resurgence of interest into new and improved vaccine adjuvants.
This interest has been stimulated by the need for new vaccines to combat problematic …