Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …

NF-κB proteins are a family of transcription factors that are of central importance in
inflammation and immunity. NF-κB also plays important roles in other processes, including …

Microplastics have gained much attention due to their prevalence and abundance in our
everyday lives. They have been detected in household items such as sugar, salt, honey …

Abstract The cytochrome P450 (P450) enzymes are the major catalysts involved in the
metabolism of drugs. bioavailability and toxicity are 2 of the most common barriers in drug …

Background: Genes encoding the circadian pacemaker in the hypothalamic suprachiasmatic
nuclei (SCN) of mammals have recently been identified, but the molecular basis of circadian …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

This review describes some of the biochemical and toxicological properties of CYP2E1,
especially as it relates to alcohol metabolism and toxicity and the establishment of human …

Acute and chronic ethanol treatment has been shown to increase the production of reactive
oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many …

Mitochondria are intimately involved in the generation of and defense against reactive
oxygen species (ROS). Mitochondria are themselves targets of oxidative stress and also …

Although there are numerous experimental data indicating that oxidative stress plays a role
in the initiation and progression of alcohol-induced liver disease (ALD), this work has yet to …