Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …

Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

Summary E2-ubiquitin (Ub) conjugates are useful chemical biology tools for studying the E3
mechanisms, but so far, the reported systems have involved either no substrates or only …

Ubiquitination is a key post-translational modification of proteins, affecting the regulation of
multiple cellular processes. Cells are equipped with over 600 ubiquitin orchestrators, called …

With the success of several clinical trials of products based on human serum albumin (HSA)
and the rapid development of nanotechnology, HSA-based nanodrug delivery systems …

Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …

Abstract Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that
mainly controls histone H2A Lys119 mono‐ubiquitination (H2AK119ub). B cell‐specific …

Simple Summary Gene expression is primarily controlled at the level of transcription, largely
due to binding of transcription factors to specific sites on DNA, namely super-enhancers and …

Post-translational modification of histones plays a central role in regulating transcription.
Methylation of histone H3 at lysines 4 (H3K4) and 79 (H3K79) play roles in activating …