Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …

Abstract Ca 2+/calmodulin-dependent protein kinase II (CaMKII) and the BK channel are
enriched at the presynaptic nerve terminal, where CaMKII associates with synaptic vesicles …

Communication between cell surface proteins and the nucleus is integral to many cellular
adaptations. In the case of ion channels in excitable cells, the dynamics of signaling to the …

Background Neurodevelopmental disorders are associated with altered patterns of neuronal
connectivity. A critical determinant of neuronal connectivity is the dendritic morphology of …

CaV1. 1 is the prototype for the other nine known CaV channel isoforms, yet it has functional
properties that make it truly atypical of this group. Specifically, CaV1. 1 is expressed solely in …

In skeletal muscle tissue, an intriguing mechanical coupling exists between two ion
channels from different membranes: the L-type voltage-gated calcium channel (Ca V 1.1) …

Abstract γ-aminobutyric acid (GABA) begins as the key excitatory neurotransmitter in newly
forming circuits, with chloride efflux from GABA type A receptors (GABA A Rs) producing …

A heterozygous Ile4898 to Thr (I4898T) mutation in the human type 1 ryanodine
receptor/Ca2+ release channel (RyR1) leads to a severe form of central core disease. We …

Ryanodine receptors (RyR) are intracellular Ca 2+ channels localized in the endoplasmic
reticulum, where they act as critical mediators of Ca 2+-induced Ca 2+ calcium release …

Hypothalamic magnocellular neuroendocrine cells have unique electrical properties and a
remarkable capacity for morphological and synaptic plasticity. Their large somatic size, their …