One promising approach for in vivo studies of cell proliferation is the FUCCI system
(fluorescent ubiquitination-based cell cycle indicator). Here, we report the development of a …

Centromeres are highly specialised chromosome domains defined by the presence of an
epigenetic mark, the specific histone H3 variant called CENP-A (centromere protein A). They …

The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing
our understanding of biological processes, not just by studying its similarities with other …

Centromeres are essential for chromosome segregation and are specified epigenetically by
the presence of the histone H3 variant CENP-A. In flies and humans, replenishment of the …

Background Centromeres depend on chromatin containing the conserved histone H3
variant CENP-A for function and inheritance, while the role of centromeric DNA repeats …

The analysis of consequences resulting after experimental elimination of gene function has
been and will continue to be an extremely successful strategy in biological research …

Centromeres are microtubule attachment sites on chromosomes defined by the enrichment
of histone variant CENP‐A‐containing nucleosomes. To preserve centromere identity …

Replication and transcription of genomic DNA requires partial disassembly of nucleosomes
to allow progression of polymerases. This presents both an opportunity to remodel the …

Centromeres mediate the conserved process of chromosome segregation, yet centromeric
DNA and the centromeric histone, CENP-A, are rapidly evolving. The rapid evolution of …

Eukaryotes duplicate their chromosomes during the cell cycle S phase using thousands of
initiation sites, tunable fork speed and megabase-long spatio-temporal replication programs …