Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Engineered enzymes for the synthesis of pharmaceuticals and other high-value products

MT Reetz, G Qu, Z Sun - Nature Synthesis, 2024 - nature.com
Catalysis has a central role in organic synthetic methodology, especially in stereoselective
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …

Advances in ultrahigh-throughput screening for directed enzyme evolution

U Markel, KD Essani, V Besirlioglu, J Schiffels… - Chemical Society …, 2020 - pubs.rsc.org
Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

[HTML][HTML] Flavoprotein monooxygenases: versatile biocatalysts

CE Paul, D Eggerichs, AH Westphal, D Tischler… - Biotechnology …, 2021 - Elsevier
Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts

MJLJ Fürst, A Gran-Scheuch, FS Aalbers… - ACS …, 2019 - ACS Publications
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …

Learning from Protein Engineering by Deconvolution of Multi‐Mutational Variants

F Hollmann, J Sanchis, MT Reetz - … Chemie International Edition, 2024 - Wiley Online Library
This review analyzes a development in biochemistry, enzymology and biotechnology that
originally came as a surprise. Following the establishment of directed evolution of …

Navigating the landscape of enzyme design: from molecular simulations to machine learning

J Zhou, M Huang - Chemical Society Reviews, 2024 - pubs.rsc.org
Global environmental issues and sustainable development call for new technologies for fine
chemical synthesis and waste valorization. Biocatalysis has attracted great attention as the …

Aqueous microdroplets containing only ketones or aldehydes undergo Dakin and Baeyer–Villiger reactions

J KyooáLee - Chemical Science, 2019 - pubs.rsc.org
The Dakin and Baeyer–Villiger (BV) oxidation reactions require addition of peroxides as
oxidants and an acid or a base as a catalyst. Reaction times range from hours to days to …

Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources

S Wu, Y Zhou, D Gerngross, M Jeschek… - Nature …, 2019 - nature.com
Engineered enzyme cascades offer powerful tools to convert renewable resources into
value-added products. Man-made catalysts give access to new-to-nature reactivities that …

Redesigning enzymes for biocatalysis: exploiting structural understanding for improved selectivity

Y Ding, G Perez-Ortiz, J Peate… - Frontiers in Molecular …, 2022 - frontiersin.org
The discovery of new enzymes, alongside the push to make chemical processes more
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …