Biocatalysis making waves in organic chemistry
U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …
biocatalysis has developed, and in doing so changed our perception of what organic …
Engineered enzymes for the synthesis of pharmaceuticals and other high-value products
MT Reetz, G Qu, Z Sun - Nature Synthesis, 2024 - nature.com
Catalysis has a central role in organic synthetic methodology, especially in stereoselective
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …
Advances in ultrahigh-throughput screening for directed enzyme evolution
U Markel, KD Essani, V Besirlioglu, J Schiffels… - Chemical Society …, 2020 - pubs.rsc.org
Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …
time. In order to exploit their full potential, enzymes often need to be re-engineered or …
[HTML][HTML] Flavoprotein monooxygenases: versatile biocatalysts
Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …
Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …
industry a poor public reputation, despite their undisputable importance to society …
Learning from Protein Engineering by Deconvolution of Multi‐Mutational Variants
F Hollmann, J Sanchis, MT Reetz - … Chemie International Edition, 2024 - Wiley Online Library
This review analyzes a development in biochemistry, enzymology and biotechnology that
originally came as a surprise. Following the establishment of directed evolution of …
originally came as a surprise. Following the establishment of directed evolution of …
Navigating the landscape of enzyme design: from molecular simulations to machine learning
J Zhou, M Huang - Chemical Society Reviews, 2024 - pubs.rsc.org
Global environmental issues and sustainable development call for new technologies for fine
chemical synthesis and waste valorization. Biocatalysis has attracted great attention as the …
chemical synthesis and waste valorization. Biocatalysis has attracted great attention as the …
Aqueous microdroplets containing only ketones or aldehydes undergo Dakin and Baeyer–Villiger reactions
J KyooáLee - Chemical Science, 2019 - pubs.rsc.org
The Dakin and Baeyer–Villiger (BV) oxidation reactions require addition of peroxides as
oxidants and an acid or a base as a catalyst. Reaction times range from hours to days to …
oxidants and an acid or a base as a catalyst. Reaction times range from hours to days to …
Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources
Engineered enzyme cascades offer powerful tools to convert renewable resources into
value-added products. Man-made catalysts give access to new-to-nature reactivities that …
value-added products. Man-made catalysts give access to new-to-nature reactivities that …
Redesigning enzymes for biocatalysis: exploiting structural understanding for improved selectivity
Y Ding, G Perez-Ortiz, J Peate… - Frontiers in Molecular …, 2022 - frontiersin.org
The discovery of new enzymes, alongside the push to make chemical processes more
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …