DNA damage foci: Meaning and significance
K Rothkamm, S Barnard, J Moquet… - Environmental and …, 2015 - Wiley Online Library
The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …
γH2AX and cancer
WM Bonner, CE Redon, JS Dickey… - Nature Reviews …, 2008 - nature.com
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
A Kinner, W Wu, C Staudt, G Iliakis - Nucleic acids research, 2008 - academic.oup.com
DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …
consequences for cell survival and the maintenance of genomic stability. In higher …
[HTML][HTML] Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research
A Ivashkevich, CE Redon, AJ Nakamura, RF Martin… - Cancer letters, 2012 - Elsevier
Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis
for a sensitive assay of DNA damage in human biopsies. The review focuses on the …
for a sensitive assay of DNA damage in human biopsies. The review focuses on the …
Persistent γH2AX: A promising molecular marker of DNA damage and aging
One of the earliest cellular responses to DNA double strand breaks (DSBs) is the
phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the …
phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the …
γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies
DNA double strand breaks (DSB) are the gravest form of DNA damage in eukaryotic cells.
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …
Histone γH2AX and poly (ADP-ribose) as clinical pharmacodynamic biomarkers
Tumor cells are often deficient in DNA damage response (DDR) pathways, and anticancer
therapies are commonly based on genotoxic treatments using radiation and/or drugs that …
therapies are commonly based on genotoxic treatments using radiation and/or drugs that …
[PDF][PDF] gamma-H2AX as protein biomarker for radiation exposure
K Rothkamm, S Horn - Ann Ist Super Sanita, 2009 - Citeseer
For large scale exposures of the human population to ionising radiation, there is a need for
cost-effective high throughput assessment of radiation exposure levels from biological …
cost-effective high throughput assessment of radiation exposure levels from biological …
Radiation-induced DNA damage in operators performing endovascular aortic repair
T El-Sayed, AS Patel, JS Cho, JA Kelly, FE Ludwinski… - Circulation, 2017 - Am Heart Assoc
Background: Radiation exposure during fluoroscopically guided interventions such as
endovascular aortic repair (EVAR) is a growing concern for operators. This study aimed to …
endovascular aortic repair (EVAR) is a growing concern for operators. This study aimed to …
[HTML][HTML] Recent developments in the use of γ-H2AX as a quantitative DNA double-strand break biomarker
The past year has seen considerable developments in the use of the DNA double-strand
breaks (DSBs) to evaluate genome alterations in cells undergoing a variety of genotoxic …
breaks (DSBs) to evaluate genome alterations in cells undergoing a variety of genotoxic …