Matrix metalloproteinases in normal pregnancy and preeclampsia
J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …
Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia
H Qu, RA Khalil - American Journal of Physiology-Heart and …, 2020 - journals.physiology.org
Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …
Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia
JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …
to maternal and fetal morbidity and mortality. Although the causative factors and …
Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia
DA Shah, RA Khalil - Biochemical pharmacology, 2015 - Elsevier
Preeclampsia is a pregnancy-associated disorder characterized by hypertension, and could
lead to maternal and fetal morbidity and mortality; however, the pathophysiological …
lead to maternal and fetal morbidity and mortality; however, the pathophysiological …
Tissue transglutaminase: A multifunctional and multisite regulator in health and disease
Z Yao, Y Fan, L Lin, RE Kellems… - Physiological …, 2024 - journals.physiology.org
Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …
broad range of cellular and metabolic functions carried out in a variety of cellular …
Preeclampsia and pregnancy-related hypertensive disorders
SA Karumanchi, JP Granger - Hypertension, 2016 - Am Heart Assoc
that serum copeptin alterations are specific to preeclampsia. Authors also noted that
copeptin levels did not correlate with circulating angiogenic factors. These data suggest that …
copeptin levels did not correlate with circulating angiogenic factors. These data suggest that …
The endothelin system: a critical player in the pathophysiology of preeclampsia
Abstract Purpose of Review Preeclampsia (PE) is a disorder of pregnancy typically
characterized by new-onset hypertension and proteinuria after gestational week 20 …
characterized by new-onset hypertension and proteinuria after gestational week 20 …
Hypoxia-independent upregulation of placental hypoxia inducible factor-1α gene expression contributes to the pathogenesis of preeclampsia
T Iriyama, W Wang, NF Parchim, A Song… - …, 2015 - Am Heart Assoc
Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial
response to hypoxia, whereas chronically elevated HIF-1α is associated with multiple …
response to hypoxia, whereas chronically elevated HIF-1α is associated with multiple …
Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia
T Iriyama, K Sun, NF Parchim, J Li, C Zhao, A Song… - Circulation, 2015 - Am Heart Assoc
Background—Preeclampsia is a prevalent hypertensive disorder of pregnancy and a
leading cause of maternal and neonatal morbidity and mortality worldwide. This pathogenic …
leading cause of maternal and neonatal morbidity and mortality worldwide. This pathogenic …
Altered maternal serum matrix metalloproteinases MMP‐2, MMP‐3, MMP‐9, and MMP‐13 in severe early‐and late‐onset preeclampsia
M Laskowska - BioMed research international, 2017 - Wiley Online Library
Objective. The aim of this study was to determine whether maternal serum matrix
metalloproteinases 2, 3, 9, and 13 levels differ in early‐and late‐onset preeclampsia and …
metalloproteinases 2, 3, 9, and 13 levels differ in early‐and late‐onset preeclampsia and …