The Mediator complex as a master regulator of transcription by RNA polymerase II

WF Richter, S Nayak, J Iwasa, DJ Taatjes - Nature Reviews Molecular …, 2022 - nature.com
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

Organization and regulation of gene transcription

P Cramer - Nature, 2019 - nature.com
The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

Functional partitioning of transcriptional regulators by patterned charge blocks

H Lyons, RT Veettil, P Pradhan, C Fornero… - Cell, 2023 - cell.com
Components of transcriptional machinery are selectively partitioned into specific
condensates, often mediated by protein disorder, yet we know little about how this specificity …

Integrator is a global promoter-proximal termination complex

EJ Wagner, L Tong, K Adelman - Molecular cell, 2023 - cell.com
Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …

Structural basis of Integrator-mediated transcription regulation

I Fianu, Y Chen, C Dienemann, O Dybkov, A Linden… - Science, 2021 - science.org
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates
paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription …

Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

L Core, K Adelman - Genes & development, 2019 - genesdev.cshlp.org
Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …

Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases

M Girbig, AD Misiaszek, CW Müller - Nature Reviews Molecular Cell …, 2022 - nature.com
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …

Causes and consequences of RNA polymerase II stalling during transcript elongation

M Noe Gonzalez, D Blears, JQ Svejstrup - Nature reviews Molecular …, 2021 - nature.com
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …

Genomic regulation of transcription and RNA processing by the multitasking Integrator complex

SA Welsh, A Gardini - Nature Reviews Molecular Cell Biology, 2023 - nature.com
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

RNA polymerase II speed: a key player in controlling and adapting transcriptome composition

L Muniz, E Nicolas, D Trouche - The EMBO journal, 2021 - embopress.org
Abstract RNA polymerase II (RNA Pol II) speed or elongation rate, ie, the number of
nucleotides synthesized per unit of time, is a major determinant of transcriptome …