Brain imaging technology has allowed researchers to conduct rigorous studies of the
dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain …

One of the sequelae of chronic alcohol abuse is malnutrition. Importantly, a deficiency in
thiamine (vitamin B1) can result in the acute, potentially reversible neurological disorder …

Background: Imaging techniques have been in widespread use in the scientific community
for more than 3 decades. They facilitate noninvasive, in vivo studies of the human brain in …

Abstract As Norman Geschwind asserted in 1965, syndromes resulting from white matter
lesions could produce deficits in higher-order functions and “disconnexion” or the …

Cognitive control refers to the internal representation, maintenance, and updating of context
information in the service of exerting control over thoughts and behavior. Deficits in cognitive …

The default mode network (DMN) comprises brain structures maximally active at rest.
Disturbance of network nodes or their connections occurs with some neuropsychiatric …

OBJECTIVES: White matter abnormalities are one of the most consistently reported findings
in neuroimaging studies of bipolar disorder (BD). We conducted an anatomical likelihood …

Over the past 40 years, rigorous examination of brain function, structure, and attending
factors through multidisciplinary research has helped identify the substrates of alcohol …

BACKGROUND: Excessive alcohol use can cause macrostructural tissue shrinkage with
regional preference for frontal systems. The extent and locus of alcoholism's effect on white …

Alcohol misuse and addiction are major international public health issues. Addiction can be
characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic …