While survival has improved for Burkitt lymphoma patients, potential differences in outcome
between pediatric and adult patients remain unclear. In both age groups, survival remains …

Forkhead box (FOX) class O (FOXO) proteins are a dynamic family of transcription factors
composed of four family members: FOXO1, FOXO3, FOXO4 and FOXO6. As context …

Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less
common but significantly more lethal when diagnosed in adults. Much of the knowledge of …

The germinal center (GC) reaction is a key process during an adaptive immune response to
T cell specific antigens. GCs are specialized structures within secondary lymphoid organs, in …

Pediatric cancers are rare diseases, and children without known germline predisposing
conditions who develop a second malignancy during developmental ages are extremely …

Sporadic Burkitt lymphoma (BL) is the most frequent tumour of children and adolescents but
a rare subtype of lymphomas in adults. To date most molecular data have been obtained …

New therapies are needed for patients with relapsed/refractory (rel/ref) diffuse large B-cell
lymphoma (DLBCL) who do not benefit from or are ineligible for stem cell transplant and …

Somatic point mutations of the FOXO1 transcription factor were reported in non-Hodgkin
lymphoma including diffuse large B-cell lymphoma, follicular lymphoma and Burkitt …

The transcription factor forkhead box O1 (FOXO1), which instructs the dark zone program to
direct germinal center (GC) polarity, is typically inactivated by phosphatidylinositol 3-kinase …

In addition to oncogenic MYC translocations, Burkitt lymphoma (BL) depends on the
germinal centre (GC) dark zone (DZ) B cell survival and proliferation programme, which is …