Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …

[HTML][HTML] MDMA-assisted psychotherapy for PTSD: growing evidence for memory effects mediating treatment efficacy

M Sarmanlu, KPC Kuypers, P Vizeli… - Progress in Neuro …, 2024 - Elsevier
The application of MDMA in conjunction with psychotherapy has in recent years seen a
resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress …

Utility of 7, 8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD

J Wang, F Gao, S Cui, S Yang, F Gao, X Wang… - Pharmacological …, 2022 - Elsevier
Astrocytic functions and brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B
(TrkB) signaling pathways are impaired in stress-related neuropsychiatric diseases …

3, 4-Methylenedioxymethamphetamine facilitates fear extinction learning

MB Young, R Andero, KJ Ressler, LL Howell - Translational psychiatry, 2015 - nature.com
Abstract Acutely administered 3, 4-methylenedioxymethamphetamine (MDMA,'ecstasy') has
been proposed to have long-term positive effects on post-traumatic stress disorder (PTSD) …

Hypothesis: the psychedelic ayahuasca heals traumatic memories via a sigma 1 receptor-mediated epigenetic-mnemonic process

A Inserra - Frontiers in pharmacology, 2018 - frontiersin.org
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and
epigenetic regulation. N, N-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) …

Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory

EJ Jaehne, JN Kent, EJ Antolasic, BJ Wright… - Translational …, 2022 - nature.com
The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is
associated with reduced activity-dependent BDNF release and increased risk for anxiety …

Memory reconsolidation

J Haubrich, K Nader - Behavioral neuroscience of learning and memory, 2018 - Springer
Scientific advances in the last decades uncovered that memory is not a stable, fixed entity.
Apparently stable memories may become transiently labile and susceptible to modifications …

Impairments to consolidation, reconsolidation, and long-term memory maintenance lead to memory erasure

J Haubrich, M Bernabo, AG Baker… - Annual Review of …, 2020 - annualreviews.org
An enduring problem in neuroscience is determining whether cases of amnesia result from
eradication of the memory trace (storage impairment) or if the trace is present but …

Increased hippocampal ProBDNF contributes to memory impairments in aged mice

M Buhusi, C Etheredge, AC Granholm… - Frontiers in aging …, 2017 - frontiersin.org
Memory decline during aging or accompanying neurodegenerative diseases, represents a
major health problem. Neurotrophins have long been considered relevant to the …

[HTML][HTML] BDNF controls object recognition memory reconsolidation

A Radiske, JI Rossato, MC Gonzalez, CA Köhler… - Neurobiology of learning …, 2017 - Elsevier
Reconsolidation restabilizes memory after reactivation. Previously, we reported that the
hippocampus is engaged in object recognition memory reconsolidation to allow …