The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

A growing epidemic of nonalcoholic fatty liver disease (NAFLD) is paralleling the increase in
the incidence of obesity and diabetes mellitus in countries that consume a Western diet. As …

Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

Several bisphenol A (BPA) analogues have been detected in environmental samples,
foodstuffs, and/or human biological samples, and there is concern regarding their potential …

Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-
disrupting chemicals (EDCs). A vast body of literature links exposure to these chemicals with …

Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …

The prevalence of obesity and atherosclerosis has substantially increased worldwide over
the past several decades. Peroxisome proliferator-activated receptors (PPARs), as fatty …

Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …

Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-
metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This …

Antioxidants are molecules characterized by function rather than common structural motifs.
Their common feature is the capability of acting “anti”-oxidants in biological systems. Owing …