The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the
primary structure for the perception of sound. Along the length of the cochlear spiral is the …

The sensory epithelia of the inner ear contain mechanosensory hair cells and non-sensory
supporting cells. Both classes of cell are heterogeneous, with phenotypes varying both …

Inner ear hair cells detect environmental signals associated with hearing, balance, and body
orientation. In humans and other mammals, significant hair cell loss leads to irreversible …

Our sense of hearing depends on precisely organized circuits that allow us to sense,
perceive, and respond to complex sounds in our environment, from music and language to …

During inner ear morphogenesis, the process of prosensory specification defines the
specific regions of the otic epithelium that will give rise to the six separate inner ear organs …

The otocyst harbors progenitors for most cell types of the mature inner ear. Developmental
lineage analyses and gene expression studies suggest that distinct progenitor populations …

Hair cells of the inner ear sensory organs originate from progenitor cells located at specific
domains of the otic vesicle: the prosensory patches. Notch signalling is necessary for …

Sensorineural hearing loss is most commonly caused by the death of hair cells in the organ
of Corti, and once lost, mammalian hair cells do not regenerate. In contrast, other vertebrates …

The signals that induce the organ of Corti and define its boundaries in the cochlea are
poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently …

Signaling through Notch receptors, which regulate cell fate decisions and embryonic
patterning, requires ligand‐induced receptor cleavage to generate the signaling active …