T‐cell exhaustion in HIV infection
C Fenwick, V Joo, P Jacquier, A Noto… - Immunological …, 2019 - Wiley Online Library
The T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
Targeting TFH cells in human diseases and vaccination: rationale and practice
The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …
[HTML][HTML] CXCL13 and its receptor CXCR5 in cancer: inflammation, immune response, and beyond
MG Kazanietz, M Durando, M Cooke - Frontiers in endocrinology, 2019 - frontiersin.org
It is well-established that the chemokine CXC motif ligand 13 (CXCL13) and its receptor, the
G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory …
G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory …
[HTML][HTML] CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
[HTML][HTML] Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
During unresolved infections, some viruses escape immunological control and establish a
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …
[HTML][HTML] Identifying immune cell infiltration and effective diagnostic biomarkers in rheumatoid arthritis by bioinformatics analysis
S Zhou, H Lu, M Xiong - Frontiers in immunology, 2021 - frontiersin.org
Background Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder
characterized by inflammatory cell infiltration, leading to persistent synovitis and joint …
characterized by inflammatory cell infiltration, leading to persistent synovitis and joint …
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
Chronic-phase HIV and simian immunodeficiency virus (SIV) replication is reduced by as
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …
CD4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
Pathophysiology of T follicular helper cells in humans and mice
Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …
induce the differentiation of B cells into plasma cells and memory cells. They are found …