It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS)
methods, which combine genome-wide transposon mutagenesis with high-throughput …

The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive
research to find alternative therapeutics. Plants rich with natural secondary metabolites are …

Antimicrobial resistance is an urgent and growing problem worldwide, both for human and
animal health. In the animal health sector actions have been taken as concerns grow …

The incidence and prevalence of non-tuberculous mycobacterial (NTM) infections have
been increasing worldwide and lately led to an emerging public health problem. Among …

A unique, protective cell envelope contributes to the broad drug resistance of the
nosocomial pathogen Acinetobacter baumannii. Here we use transposon insertion …

Staphylococcus aureus is one of the main pathogens involved in dairy cow mastitis.
Monitoring of antibiotic use would prove useful to assess the risk of Staph. aureus in raw …

Central metabolic pathways control virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …

Chemotherapy for tuberculosis (TB) is lengthy and could benefit from synergistic adjuvant
therapeutics that enhance current and novel drug regimens. To identify genetic determinants …

Introduction: The development of new antimicrobials has become an urgent priority because
of a global challenge emerging from the rise of antimicrobial resistant pathogens. Areas …

FmtA is a penicillin-recognizing protein (PRP) with novel hydrolytic activity toward the ester
bond between d-Ala and the backbone of teichoic acids. Teichoic acids are polyol …