In recent years, RNA-sequencing (RNA-seq) has emerged as a powerful technology for
transcriptome profiling. For a given gene, the number of mapped reads is not only …

Epigenomic profiling by chromatin immunoprecipitation coupled with massively parallel
DNA sequencing (ChIP-seq) is a prevailing methodology used to investigate chromatin …

Many diseases are caused by perturbations of cellular signaling pathways and related
pathway networks as a result of genetic aberrations. These perturbations are manifested by …

In the life sciences, many measurement methods yield only the relative abundances of
different components in a sample. With such relative—or compositional—data, differential …

To understand regulatory systems, it would be useful to uniformly determine how different
components contribute to the expression of all other genes. We therefore monitored mRNA …

Understanding preimplantation development is important both for basic reproductive biology
and for practical applications including regenerative medicine and livestock breeding …

Upland cotton (Gossypium hirsutum) produces the most widely used natural fibers, yet the
regulatory mechanisms governing fiber cell elongation are not well understood. Through …

To monitor eukaryotic mRNA metabolism, we developed comparative dynamic
transcriptome analysis (cDTA). cDTA provides absolute rates of mRNA synthesis and decay …

Many temperate plant species such as Arabidopsis thaliana are able to increase their
freezing tolerance when exposed to low, nonfreezing temperatures in a process called cold …

Collagens are the most abundant proteins in the human body, important in maintenance of
tissue structure and hemostasis. Here we report that collagens are high affinity ligands for …