Depression is the most prevalent psychiatric disorder in the world, affecting 4.4% of the
global population. Despite an array of treatment modalities, depressive disorders remain …

5-Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a
substance isolated from blood. The neural effects of 5-HT have been well investigated and …

Objective To assess whether use of specific selective serotonin reuptake inhibitors (SSRIs)
or venlafaxine in early pregnancy is associated with an increased risk of birth defects, with …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

Estimates of the lifetime risk of major depression in women range from 10% to 25%, peaking
during the reproductive years. Today, selective serotonin-reuptake inhibitors (SSRIs) are the …

Background In 2005, the FDA cautioned that exposure to paroxetine, a selective serotonin
reuptake inhibitor (SSRI), during the first trimester of pregnancy may increase the risk of …

BACKGROUND Although prescription drug use is common during pregnancy, the human
teratogenic risks are undetermined for more than 90% of drug treatments approved in the …

Objective Antidepressant use during gestation has been associated with risk of major
congenital malformations but estimates can lack statistical power or be confounded by …

OBJECTIVE: To estimate the risk of major congenital anomalies after exposure to selective
serotonin reuptake inhibitors during pregnancy. METHODS: A retrospective cohort study …

Background—The purpose of this study was to investigate whether rats dosed with serotonin
develop changes similar to those seen in human carcinoid heart disease. Methods and …