Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …

From yeast to mammals, autophagy is an important mechanism for sustaining cellular
homeostasis through facilitating the degradation and recycling of aged and cytotoxic …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy has burgeoned rapidly as a field of study because of its evolutionary
conservation, the diversity of intracellular cargoes degraded and recycled by this machinery …

The lysosome is a degradative organelle, and its fusion with other organelles is strictly
regulated. In contrast to fusion with the late endosome, the mechanisms underlying …

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a
portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically …