Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …

Psoriasis is one of the most common chronic inflammatory skin diseases, affecting 3% of the
world's population, and approximately one-third of patients with psoriasis will eventually …

Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …

Background The complications and sequelae of coronavirus disease 2019 (COVID-19) and
their effect on long-term health are unclear, and the trajectory of associated immune …

Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with
long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin …

Spleen tyrosine kinase (SYK) is a critical immune signaling molecule and therapeutic target.
We identified damaging monoallelic SYK variants in six patients with immune deficiency …

Abstract T helper 17 (Th17) cells have been involved in the pathogenesis of many
autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid …

Overnutrition causes obesity, a global health problem without any effective therapy. Obesity
is characterized by low-grade inflammation, which predisposes individuals to metabolic …

Background The co-circulation of flaviviruses in tropical regions has led to the hypothesis
that immunity generated by a previous dengue infection could promote severe disease …