Abstract C2H2 zinc-finger (ZF) proteins form the largest family of DNA-binding transcription
factors coded by mammalian genomes. In a typical DNA-binding ZF module, there are …

In humans, specific aberrations in β-globin results in sickle cell disease and β-thalassemia,
symptoms of which can be ameliorated by increased expression of fetal globin (HbF). Two …

CTCF is a zinc finger protein associated with transcription regulation that also acts as a
barrier factor for topologically associated domains (TADs) generated by cohesin via loop …

The largest group of transcription factors in higher eukaryotes are C2H2 proteins, which
contain C2H2‐type zinc finger domains that specifically bind to DNA. Few well‐studied …

The post-genomic era has ushered in the extensive application of epigenetic editing tools,
allowing for precise alterations of gene expression. The use of reprogrammable editors that …

As an essential regulator of higher-order chromatin structures, CTCF is a highly-conserved
DNA binding protein with a central DNA-binding domain of 11 tandem zinc fingers, which …

Acetylation of lysine residues in the tail domain of histone H3 is well characterized.
However, acetyl-lysines in the histone globular domain also hold regulatory potential …