Physical exercise and neuroinflammation in major depressive disorder

ZM Ignácio, RS da Silva, ME Plissari, J Quevedo… - Molecular …, 2019 - Springer
Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied
prognosis, chronic course, and duration of illness with reduced quality of life. One factor that …

Implications of physical exercise on episodic memory and anxiety: The role of the serotonergic system

R Illesca-Matus, NM Ardiles, F Munoz… - International Journal of …, 2023 - mdpi.com
There is a growing interest in investigating the effects of physical exercise on cognitive
performance, particularly episodic memory. Similarly, an increasing number of studies in …

Ginsenoside-Rg1 synergized with voluntary running exercise protects against glial activation and dysregulation of neuronal plasticity in depression

W Wang, L Wang, L Wang, Y Li, T Lan, C Wang… - Food & function, 2023 - pubs.rsc.org
Depression is a common psychological disease accompanied by mental disorders and
somatic symptoms. However, the underlying mechanisms regarding the pathogenesis of …

Exercise increases mTOR signaling in brain regions involved in cognition and emotional behavior

BA Lloyd, HS Hake, T Ishiwata, CE Farmer… - Behavioural brain …, 2017 - Elsevier
Exercise can enhance learning and memory and produce resistance against stress-related
psychiatric disorders such as depression and anxiety. In rats, these beneficial effects of …

The effects of aerobic exercise on depression-like, anxiety-like, and cognition-like behaviours over the healthy adult lifespan of C57BL/6 mice

JA Morgan, G Singhal, F Corrigan, EJ Jaehne… - Behavioural brain …, 2018 - Elsevier
Preclinical studies have demonstrated exercise improves various types of behaviours such
as anxiety-like, depression-like, and cognition-like behaviours. However, these findings …

Environmental enrichment and physical exercise attenuate the depressive-like effects induced by social isolation stress in rats

JC Brenes, J Fornaguera… - Frontiers in …, 2020 - frontiersin.org
We assessed the antidepressant-like effects of environmental enrichment (EE) and physical
exercise (PE) compared with the selective serotonin reuptake inhibitor fluoxetine against the …

Effects of exercise on mitochondrial function, neuroplasticity and anxio-depressive behavior of mice

AS Aguiar Jr, E Stragier, D da Luz Scheffer, AP Remor… - Neuroscience, 2014 - Elsevier
The present study was aimed at analyzing the effects of physical exercise on mitochondrial
physiology, anxio-depressive-like behaviors and neuroplasticity in mice. Adult C57BL/6J …

The role of PGC-1α/UCP2 signaling in the beneficial effects of physical exercise on the brain

VJ de Oliveira Bristot, AC de Bem Alves… - Frontiers in …, 2019 - frontiersin.org
In understanding the pathology of neurological diseases, the role played by brain energy
metabolism is gaining prominence. Animal models have demonstrated that regular physical …

Physical activity modulates common neuroplasticity substrates in major depressive and bipolar disorder

C Phillips - Neural Plasticity, 2017 - Wiley Online Library
Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of
individuals worldwide. Although the biogenic amine model has provided some clinical utility …

Exercise more efficiently regulates the maturation of newborn neurons and synaptic plasticity than fluoxetine in a CUS-induced depression mouse model

X Liang, J Tang, Y Qi, Y Luo, C Yang, X Dou… - Experimental …, 2022 - Elsevier
Depression, a common and important cause of morbidity and mortality worldwide, is
commonly treated with antidepressants, electric shock and psychotherapy. Recently …