Recent developments and modification strategies in electrochemical sensors based on green nanomaterials for catechol detection
Catechol (CC), an important phenolic compound, poses a significant threat to human health
due to its toxicity and is widely available in natural water resources. In addition, CC is the …
due to its toxicity and is widely available in natural water resources. In addition, CC is the …
STAT5A and STAT5B—twins with different personalities in hematopoiesis and leukemia
The transcription factors STAT5A and STAT5B have essential roles in survival and
proliferation of hematopoietic cells—which have been considered largely redundant …
proliferation of hematopoietic cells—which have been considered largely redundant …
STAT3, the challenge for chemotherapeutic and radiotherapeutic efficacy
PL Yang, LX Liu, EM Li, LY Xu - Cancers, 2020 - mdpi.com
Simple Summary STAT3, an oncogene, contributes to insensitivity of chemotherapy and
radiotherapy in tumor, reduces the clinical efficacy. Meanwhile, STAT3β, a STAT3 splicing …
radiotherapy in tumor, reduces the clinical efficacy. Meanwhile, STAT3β, a STAT3 splicing …
Selective modulation of dynamic protein complexes
JM Garlick, AK Mapp - Cell chemical biology, 2020 - cell.com
Dynamic proteins perform critical roles in cellular machines, including those that control
proteostasis, transcription, translation, and signaling. Thus, dynamic proteins are prime …
proteostasis, transcription, translation, and signaling. Thus, dynamic proteins are prime …
Strain engineered biocompatible h-WO3 nanofibers based highly selective and sensitive chemiresistive platform for detection of Catechol in blood sample
S Veeralingam, S Badhulika - Materials Science and Engineering: C, 2020 - Elsevier
In this work, we demonstrate a simple, low-cost biocompatible 1D–WO 3 electrospun
nanofibers based strain-induced high-performance chemiresistive catechol sensor. WO 3 …
nanofibers based strain-induced high-performance chemiresistive catechol sensor. WO 3 …
Stafia‐1: a STAT5a‐Selective Inhibitor Developed via Docking‐Based Screening of in Silico O‐Phosphorylated Fragments
K Natarajan, D Müller‐Klieser… - … –A European Journal, 2020 - Wiley Online Library
We present a new approach for the identification of inhibitors of phosphorylation‐dependent
protein–protein interaction domains, in which phenolic fragments are adapted by in silico O …
protein–protein interaction domains, in which phenolic fragments are adapted by in silico O …
Stafiba: A STAT5‐Selective Small‐Molecule Inhibitor
KS Eckhardt, T Münzel, J Gräb, T Berg - Chembiochem, 2023 - Wiley Online Library
The transcription factors STAT5a and STAT5b are constitutively active in many human
tumors. Combined inhibition of both STAT5 proteins is a valuable approach with promising …
tumors. Combined inhibition of both STAT5 proteins is a valuable approach with promising …
A high-throughput fluorescence polarization-based assay for the SH2 domain of STAT4
A Berg, M Gräber, S Schmutzler, R Hoffmann… - Methods and …, 2022 - mdpi.com
The signal transducer and activation of transcription (STAT) proteins are a family of Src
homology 2 (SH2) domain-containing transcription factors. The family member STAT4 is a …
homology 2 (SH2) domain-containing transcription factors. The family member STAT4 is a …
ATP inhibits the transcription factor STAT5b
A Berg, B Sperl, T Berg - ChemBioChem, 2019 - Wiley Online Library
Although naturally occurring low‐molecular‐weight compounds have many known roles
within the cell, these do not usually involve the direct inhibition of protein–protein …
within the cell, these do not usually involve the direct inhibition of protein–protein …
Asymmetrically Substituted m‐Terphenyl Phosphates Inhibit the Transcription Factor STAT5a
D Müller‐Klieser, T Berg - ChemBioChem, 2022 - Wiley Online Library
We recently presented Stafia‐1 as the first chemical entity that inhibits the transcription factor
STAT5a with selectivity over the highly homologous STAT5b. Stafia‐1, which was identified …
STAT5a with selectivity over the highly homologous STAT5b. Stafia‐1, which was identified …