Recent developments and modification strategies in electrochemical sensors based on green nanomaterials for catechol detection

YO Donar, S Bilge, D Bayramoğlu, B Özoylumlu… - Trends in Environmental …, 2023 - Elsevier
Catechol (CC), an important phenolic compound, poses a significant threat to human health
due to its toxicity and is widely available in natural water resources. In addition, CC is the …

STAT5A and STAT5B—twins with different personalities in hematopoiesis and leukemia

B Maurer, S Kollmann, J Pickem, A Hoelbl-Kovacic… - Cancers, 2019 - mdpi.com
The transcription factors STAT5A and STAT5B have essential roles in survival and
proliferation of hematopoietic cells—which have been considered largely redundant …

STAT3, the challenge for chemotherapeutic and radiotherapeutic efficacy

PL Yang, LX Liu, EM Li, LY Xu - Cancers, 2020 - mdpi.com
Simple Summary STAT3, an oncogene, contributes to insensitivity of chemotherapy and
radiotherapy in tumor, reduces the clinical efficacy. Meanwhile, STAT3β, a STAT3 splicing …

Selective modulation of dynamic protein complexes

JM Garlick, AK Mapp - Cell chemical biology, 2020 - cell.com
Dynamic proteins perform critical roles in cellular machines, including those that control
proteostasis, transcription, translation, and signaling. Thus, dynamic proteins are prime …

Strain engineered biocompatible h-WO3 nanofibers based highly selective and sensitive chemiresistive platform for detection of Catechol in blood sample

S Veeralingam, S Badhulika - Materials Science and Engineering: C, 2020 - Elsevier
In this work, we demonstrate a simple, low-cost biocompatible 1D–WO 3 electrospun
nanofibers based strain-induced high-performance chemiresistive catechol sensor. WO 3 …

Stafia‐1: a STAT5a‐Selective Inhibitor Developed via Docking‐Based Screening of in Silico O‐Phosphorylated Fragments

K Natarajan, D Müller‐Klieser… - … –A European Journal, 2020 - Wiley Online Library
We present a new approach for the identification of inhibitors of phosphorylation‐dependent
protein–protein interaction domains, in which phenolic fragments are adapted by in silico O …

Stafiba: A STAT5‐Selective Small‐Molecule Inhibitor

KS Eckhardt, T Münzel, J Gräb, T Berg - Chembiochem, 2023 - Wiley Online Library
The transcription factors STAT5a and STAT5b are constitutively active in many human
tumors. Combined inhibition of both STAT5 proteins is a valuable approach with promising …

A high-throughput fluorescence polarization-based assay for the SH2 domain of STAT4

A Berg, M Gräber, S Schmutzler, R Hoffmann… - Methods and …, 2022 - mdpi.com
The signal transducer and activation of transcription (STAT) proteins are a family of Src
homology 2 (SH2) domain-containing transcription factors. The family member STAT4 is a …

ATP inhibits the transcription factor STAT5b

A Berg, B Sperl, T Berg - ChemBioChem, 2019 - Wiley Online Library
Although naturally occurring low‐molecular‐weight compounds have many known roles
within the cell, these do not usually involve the direct inhibition of protein–protein …

Asymmetrically Substituted m‐Terphenyl Phosphates Inhibit the Transcription Factor STAT5a

D Müller‐Klieser, T Berg - ChemBioChem, 2022 - Wiley Online Library
We recently presented Stafia‐1 as the first chemical entity that inhibits the transcription factor
STAT5a with selectivity over the highly homologous STAT5b. Stafia‐1, which was identified …