Applying Spatiotemporal Modeling of Cell Dynamics to Accelerate Drug Development
Cells act as physical computational programs that utilize input signals to orchestrate
molecule-level protein–protein interactions (PPIs), generating and responding to forces …
molecule-level protein–protein interactions (PPIs), generating and responding to forces …
Collective migration of cells in geometric spaces: Intrinsic correlation length racing against extrinsic confinement size
BC Wang, GK Xu - Journal of the Mechanics and Physics of Solids, 2023 - Elsevier
Many experiments showed that cell groups can exhibit various impressive motion modes
(eg, global rotation and local swirling) in different-sized geometrical spaces, with the …
(eg, global rotation and local swirling) in different-sized geometrical spaces, with the …
Cell-size-dependent regulation of Ezrin dictates epithelial resilience to stretch by countering myosin-II-mediated contractility
G Chouhan, NS Lewis, V Ghanekar, SRK Ainavarapu… - Cell Reports, 2024 - cell.com
The epithelial adaptations to mechanical stress are facilitated by molecular and tissue-scale
changes that include the strengthening of junctions, cytoskeletal reorganization, and cell …
changes that include the strengthening of junctions, cytoskeletal reorganization, and cell …
Size-induced motion mode transitions in collective cell invasion toward free spaces
BC Wang, Y Lin, GK Xu - Soft Matter, 2023 - pubs.rsc.org
Collective cell migration plays a vital role in various physiological and pathological
processes, such as embryonic development and tumor metastasis. Recent experiments …
processes, such as embryonic development and tumor metastasis. Recent experiments …