Cell-extracellular matrix contacts are points on cell surfaces where adhesion receptors
tether cells to matrix and are linked intracellularly to cytoskeletal components. These …

Many proline-rich proteins participate in delivering actin monomers to specific cellular
locations where actin-rich membrane protrusions, such as ruffles, filopodia and microspikes …

Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases,
including myocardial infarction and stroke. Platelet adhesion and aggregation during …

The formation of focal adhesions that mediate alterations of cell shape and movement is
controlled by a mechanochemical mechanism in which cytoskeletal tensional forces drive …

Activation of the canonical mitogen-activated protein kinase (MAPK) cascade by soluble
mitogens is blocked in non-adherent cells. It is also blocked in cells in which the cAMP …

Endoglin is a component of the transforming growth factor-β receptor complex abundantly
expressed at the surface of endothelial cells and plays an important role in cardiovascular …

Small extracellular vesicles (sEVs) have emerged as noninvasive biomarkers in liquid
biopsy due to their significant function in pathology and physiology. However, the …

Podocyte detachment due to mechanical stress is a common issue in hypertension-induced
kidney disease. This study highlights the role of zyxin for podocyte stability and function. We …

The function of vasodilator-stimulated phosphoprotein (VASP) in motility is analyzed using a
biomimetic motility assay in which ActA-coated microspheres propel themselves in a …

Profilin-1 (Pfn1) is a ubiquitously expressed actin-monomer binding protein that has been
linked to many cellular activities ranging from control of actin polymerization to gene …