Abstract Systems medicine is founded on a mechanism-based approach and identifies in
this way specific therapeutic targets. This approach has been applied for the transcription …

Atherosclerosis is a chronic vascular disease in which oxidative stress and inflammation are
commonly implicated as major causative factors. Identification of novel strategies that …

Management of diabetic foot ulcers (DFUs) is a great challenge for clinicians. Although the
oxygen-ozone treatment improves the diabetic outcome, there are few clinical trials to verify …

Background Air pollution has been shown to have adverse effects on many health outcomes
including cardiorespiratory diseases and cancer. However, evidence on the effects of …

Background Investigations on the potential effects of high air pollution exposure before
pregnancy on adverse pregnancy outcomes are limited, and it is unknown whether air …

Background Epidemiological studies suggest that both ambient ozone (O 3) and
temperature were associated with increased risks of adverse birth outcomes. However, very …

Importance Although certain air pollutants have been associated with adverse obstetric
outcomes, evidence regarding the association of ozone (O 3) exposure with the risk of …

Osteoarthritis (OA) is a dynamic condition characterized by cartilage damage and synovial
inflammation. Ozone (O3) shows potential therapeutic effects owing to its anti‐inflammatory …

Ozone therapy has been widely used to treat many skin diseases, including infections,
allergic dermatosis, and skin ulcers. However, its efficacy as a treatment for psoriasis is …

The beneficial effect of low doses of ozone on wound healing has been well documented
and attributed mainly to its bactericidal and pro-oxidant properties. Because ozone itself …