Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Triple-negative (TNBC) is the most lethal subtype of breast cancer owing to high
heterogeneity, aggressive nature, and lack of treatment options. Chemotherapy remains the …

Cancer stem cells (CSCs) are self-renewing cells that facilitate tumor initiation, promote
metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many …

The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle
in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in …

Distant metastasis accounts for the vast majority of deaths in patients with cancer. Breast
cancer exhibits a distinct metastatic pattern commonly involving bone, liver, lung, and brain …

During mammalian embryonic development, primary cilia transduce and regulate several
signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most …

Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …