Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
[HTML][HTML] Animal models in translational medicine: Validation and prediction
T Denayer, T Stöhr, M Van Roy - New Horizons in Translational Medicine, 2014 - Elsevier
Despite large investments in drug development, the overall success rate of drugs during
clinical development remains low. One prominent explanation is flawed preclinical research …
clinical development remains low. One prominent explanation is flawed preclinical research …
Patient-derived tumour xenografts as models for oncology drug development
Progress in oncology drug development has been hampered by a lack of preclinical models
that reliably predict clinical activity of novel compounds in cancer patients. In an effort to …
that reliably predict clinical activity of novel compounds in cancer patients. In an effort to …
Costs and causes of oncology drug attrition with the example of insulin-like growth factor-1 receptor inhibitors
V Jentzsch, L Osipenko, JW Scannell… - JAMA Network …, 2023 - jamanetwork.com
Importance The development of oncology drugs is expensive and beset by a high attrition
rate. Analysis of the costs and causes of translational failure may help to reduce attrition and …
rate. Analysis of the costs and causes of translational failure may help to reduce attrition and …
Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer
Insulin and insulin-like growth factor (IGF) signaling system, commonly known for fine-tuning
numerous biological processes, has lately made its mark as a much sought-after therapeutic …
numerous biological processes, has lately made its mark as a much sought-after therapeutic …
Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts
Background The success of agents that reverse T-cell inhibitory signals, such as anti-PD-
1/PD-L1 therapies, has reinvigorated cancer immunotherapy research. However, since only …
1/PD-L1 therapies, has reinvigorated cancer immunotherapy research. However, since only …
Regulation of IGF-1 signaling by microRNAs
The insulin-like growth factor 1 (IGF-1) signaling pathway regulates critical biological
processes including development, homeostasis, and aging. Dysregulation of this pathway …
processes including development, homeostasis, and aging. Dysregulation of this pathway …
Can we unlock the potential of IGF-1R inhibition in cancer therapy?
H King, T Aleksic, P Haluska, VM Macaulay - Cancer treatment reviews, 2014 - Elsevier
IGF-1R inhibitors arrived in the clinic accompanied by optimism based on preclinical activity
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …
Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes
R Yerushalmi, KA Gelmon, S Leung, D Gao… - Breast cancer research …, 2012 - Springer
Insulin-like growth factor-1 receptor (IGF-1R) is expressed in normal and malignant breast
tissue and has been implicated in cell survival and resistance to cytotoxic therapies. We …
tissue and has been implicated in cell survival and resistance to cytotoxic therapies. We …
Dual inhibition of MEK and PI3K pathway in KRAS and BRAF mutated colorectal cancers
Colorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative
genetic mutations. Genetic mutations in the phosphatidylinositol-3 kinase (PI3K) and the …
genetic mutations. Genetic mutations in the phosphatidylinositol-3 kinase (PI3K) and the …