Background Several studies around the world support the hypothesis that genetic
polymorphisms involved in folate metabolism could be related to the maternal risk for Down …

Mutations of ion channels and G-protein-coupled receptors (GPCRs) are not uncommon and
can lead to cardiovascular diseases. Given previously reported multiple factors associated …

Objective The objective was to investigate the association between maternal
methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms, crucial for DNA …

Are the maternal gene variants MTHFR: c. 665C> T, MTHFR: c. 1286A> C, MTR: c. 2756A>
G, MTRR: c. 66A> G, RFC1: c. 80C> T and TCN2: c. 776G> C and blood markers of the …

Background: Down syndrome (DS) is a complex genetic disease that is caused by having
three copies of chromosome 21. A possible association between polymorphisms in maternal …

Individuals with Down syndrome (DS) have numerous comorbidities due to trisomy 21.
However, virtual reality-based therapy (VRT) has been used nowadays as a learning and …

Аннотация Введение. Мутантные аллели генов ферментов фолатного цикла могут
привести к значимым нарушениям его функции и различной тяжести патологии …

Methylation is a biochemical process involving the addition of a methyl group (-CH3) to
various chemical compounds. It plays a crucial role in maintaining the homeostasis of the …

Down syndrome (DS) is the leading cause of intellectual disability, yet the factors
contributing to its occurrence remain largely unknown. In this study, we investigated the …

MTHFR is an essential enzyme in the folate pathway. Down syndrome (DS), which affects 1
in 700 live births, is common chromosomal aneuploidy with documented dysregulation in …