[HTML][HTML] Nano-enhanced drug delivery and therapeutic ultrasound for cancer treatment and beyond

P Tharkar, R Varanasi, WSF Wong, CT Jin… - … in Bioengineering and …, 2019 - frontiersin.org
While ultrasound is most widely known for its use in diagnostic imaging, the energy carried
by ultrasound waves can be utilized to influence cell function and drug delivery …

Nucleation, mapping and control of cavitation for drug delivery

E Stride, C Coussios - Nature Reviews Physics, 2019 - nature.com
Acoustically driven bubbles produce a range of mechanical, thermal and chemical effects
that can be exploited in drug delivery applications. Significant improvements in the targeting …

Applications of ultrasound-mediated drug delivery and gene therapy

J Sitta, CM Howard - International Journal of Molecular Sciences, 2021 - mdpi.com
Gene therapy has continuously evolved throughout the years since its first proposal to
develop more specific and effective transfection, capable of treating a myriad of health …

Sonoporation: Past, present, and future

J Rich, Z Tian, TJ Huang - Advanced materials technologies, 2022 - Wiley Online Library
A surge of research in intracellular delivery technologies is underway with the increased
innovations in cell‐based therapies and cell reprogramming. Particularly, physical cell …

[HTML][HTML] Opening of endothelial cell–cell contacts due to sonoporation

I Beekers, M Vegter, KR Lattwein, F Mastik… - Journal of controlled …, 2020 - Elsevier
Ultrasound insonification of microbubbles can locally increase vascular permeability to
enhance drug delivery. To control and optimize the therapeutic potential, we need to better …

Buckling of lipidic ultrasound contrast agents under quasi-static load

G Chabouh, B van Elburg… - … of the Royal …, 2023 - royalsocietypublishing.org
Collapse of lipidic ultrasound contrast agents under high-frequency compressive load has
been historically interpreted by the vanishing of surface tension. By contrast, buckling of …

Ultrasound contrast: gas microbubbles in the vasculature

AL Klibanov - Investigative Radiology, 2021 - journals.lww.com
Gas-filled microbubbles are currently in clinical use as blood pool contrast agents for
ultrasound imaging. The goal of this review is to discuss the trends and issues related to …

Polymeric materials for ultrasound imaging and therapy

RA Barmin, MJ Moosavifar, A Dasgupta… - Chemical …, 2023 - pubs.rsc.org
Ultrasound (US) is routinely used for diagnostic imaging and increasingly employed for
therapeutic applications. Materials that act as cavitation nuclei can improve the resolution of …

An overview of cell membrane perforation and resealing mechanisms for localized drug delivery

S He, D Singh, B Helfield - Pharmaceutics, 2022 - mdpi.com
Localized and reversible plasma membrane disruption is a promising technique employed
for the targeted deposition of exogenous therapeutic compounds for the treatment of …

A multicellular brain spheroid model for studying the mechanisms and bioeffects of ultrasound-enhanced drug penetration beyond the blood‒brain barrier

AN Paranjape, L D'Aiuto, W Zheng, X Chen… - Scientific Reports, 2024 - nature.com
The blood‒brain barrier (BBB) acts as a hindrance to drug therapy reaching the brain. With
an increasing incidence of neurovascular diseases and brain cancer metastases, there is a …