The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …

Active neurons increase their energy supply by dilating nearby arterioles and capillaries.
This neurovascular coupling underlies blood oxygen level–dependent functional imaging …

Astrocytes are glial cells that are distributed throughout the central nervous system in an
arrangement optimal for chemical and physical interaction with neuronal synapses and …

To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …

The brain is endowed with highly specialized vasculature that is both structurally and
functionally unique compared to vasculature supplying peripheral organs. The blood–brain …

Age-related phenotypic changes of cerebromicrovascular endothelial cells lead to
dysregulation of cerebral blood flow and blood-brain barrier disruption, promoting the …