Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Calcium (Ca2+) uptake into the mitochondrial matrix is critically important to cellular function.
As a regulator of matrix Ca2+ levels, this flux influences energy production and can initiate …

Myofascial pain syndrome is an important health problem. It affects a majority of the general
population, impairs mobility, causes pain, and reduces the overall sense of well‐being …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Rationale: Transverse tubules (TTs) couple electric surface signals to remote intracellular
Ca2+ release units (CRUs). Diffraction-limited imaging studies have proposed loss of TT …

Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca2+ release
from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to …

The canonical atrial myocyte (AM) is characterized by sparse transverse tubule (TT)
invaginations and slow intracellular Ca2+ propagation but exhibits rapid contractile …

In both excitable and nonexcitable cells, diverse physiological processes are linked to
different calcium microdomains within nanoscale junctions that form between the plasma …

X-ROS signaling is a novel redox signaling pathway that links mechanical stress to changes
in [Ca2+] i. This pathway is activated rapidly and locally within a muscle cell under …

Aims In atrial fibrillation (AF), abnormalities in Ca2+ release contribute to arrhythmia
generation and contractile dysfunction. We explore whether ryanodine receptor (RyR) …