The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
ongoing global outbreak of a coronavirus disease (herein referred to as COVID-19). Other …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Motivation Improvements in DNA sequencing technology and computational methods have
led to a substantial increase in the creation of high-quality genome assemblies of many …

The development of multiple chromosome-scale reference genome sequences in many
taxonomic groups has yielded a high-resolution view of the patterns and processes of …

The rich diversity of morphology and behavior displayed across primate species provides an
informative context in which to study the impact of genomic diversity on fundamental …

Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …

The MUMmer system and the genome sequence aligner nucmer included within it are
among the most widely used alignment packages in genomics. Since the last major release …

Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Genomes represent the starting point of genetic studies. Since the discovery of DNA
structure, scientists have devoted great efforts to determine their sequence in an exact way …

In order to provide a comprehensive resource for human structural variants (SVs), we
generated long-read sequence data and analyzed SVs for fifteen human genomes. We …