Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …

Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Dementia is defined as a gradual cognitive impairment that interferes with everyday tasks,
and is a leading cause of dependency, disability, and mortality. According to the current …

Neurodegenerative disorders are among the most studied issues both in medicine and
pharmacy. Despite long and extensive research, there is no effective treatment prescribed …

Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …

Higher eukaryotes' life is impossible without copper redox activity and, literally, every breath
we take biochemically demonstrates this. However, this dependence comes at a …

Abstract Development of multitargeted ligands have demonstrated remarkable efficiency as
potential therapeutics for Alzheimer's disease (AD). Herein, we reported a new series of …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of
extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) …

Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system.
The main pathophysiological mechanisms involve cholinergic neurotransmission, beta …