Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to
play a critical role in the development of AD neuropathology. The overexpression of the …

At present, there may be over 210,000 people with Down syndrome (DS) over the age of 55
in the United States (US) who have significant needs for augmented services due to …

Background The life expectancy of adults with Down syndrome (DS) has significantly
increased in the last decades. We aim to describe the main demographic and clinical …

Objectives To correlate cardiovascular risk factors (eg, hypertension, obesity,
hypercholesterolemia, hypertriglyceridemia, hyperglycemia, sedentariness) in childhood …

Down syndrome (DS) is the main genetic cause of intellectual disability worldwide. The
overexpression of the Amyloid Precursor Protein, present in chromosome 21, leads to β …

METHODS: Youth with (n= 150) and without (n= 103) DS of comparable age (10–20 years),
sex, race, ethnicity, and BMI percentile underwent whole-body dual-energy X-ray …

Down's syndrome results from increased genetic material on all or a portion of chromosome
21 and is characterized by intellectual disability and risk for comorbidities involving multiple …

We aimed to describe anthropometric differences in weight-related disorders between adults
with Down syndrome (DS) and healthy controls, as well as their disparate impact on glucose …

Down syndrome (DS) is a common cause of intellectual disability and is also associated with
early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21 …

One of the approaches to the research of the problem of aging is the study of genetic
pathologies leading to accelerated aging, such as the Hutchinson-Gilford progeria …